Gumweed (Grindelia spp.) has a long history of use in traditional medicine, particularly among Native American groups and 19th-century herbalists in North America. It was commonly applied topically to minor wounds, scratches, and abrasions due to its sticky resin, which forms a protective barrier over the skin. Historical ethnobotanical records describe its use as a poultice or wash for skin irritations, minor cuts, and abrasions. The sticky exudate was thought to shield wounds from contamination and promote healing, although these benefits were based on empirical observation rather than controlled study.

Modern scientific research into Gumweed’s efficacy for wound healing is limited. Some laboratory studies have identified anti-inflammatory and antimicrobial compounds in Grindelia species, such as diterpenes and flavonoids, which could theoretically aid in minor wound care. However, there are no robust clinical trials or systematic reviews confirming its effectiveness or safety for scratches and abrasions. As a result, while its traditional use is well-documented, scientific validation remains insufficient, so the evidence rating is moderate at best.