Polyvinylpyrrolidone (PVP), also known as povidone, is commonly used in topical formulations for minor wounds, scratches, and abrasions—primarily as part of povidone-iodine (an antiseptic complex of PVP and iodine). The scientific rationale for its use centers around its excellent film-forming and moisture-retentive properties. PVP itself is a synthetic polymer that helps create a protective barrier over the wound when applied as a gel or solution, which can help maintain a moist environment conducive to healing and reduce the risk of infection by preventing contamination. Additionally, its use in medical products is supported by its non-toxic, non-irritant, and biocompatible characteristics.

However, the direct evidence supporting PVP alone (without iodine) for wound healing is limited. Most clinical studies and systematic reviews focus on the efficacy of povidone-iodine, which leverages the antimicrobial action of iodine, rather than the wound healing support offered by PVP itself. Some in vitro and in vivo studies suggest that PVP can accelerate wound closure due to its ability to form hydrogels and promote cell migration, but robust clinical data in humans are sparse. Therefore, while PVP is scientifically justified as a supportive film-former in wound care products, the specific evidence for its use in treating scratches and abrasions (outside of its role as a carrier for iodine or in combination with other actives) is modest, meriting a moderate evidence rating.