Synopsis

Source of validity: Scientific
Rating (out of 5): 2

St. John's Wort (Hypericum perforatum) is a herbal remedy traditionally used for mood disorders, particularly mild to moderate depression. Its application for Seasonal Affective Disorder (SAD) is based on its antidepressant properties. Scientific studies have shown that St. John’s Wort can be as effective as certain prescription antidepressants for mild to moderate major depression, likely by inhibiting the reuptake of neurotransmitters such as serotonin, dopamine, and norepinephrine.

However, evidence specifically targeting SAD is limited. A small number of randomized controlled trials have examined St. John’s Wort in SAD, sometimes in combination with light therapy. These studies suggest a potential benefit, but results are not robust or consistent enough to warrant strong recommendations for its use in SAD specifically. Major clinical guidelines generally consider evidence for St. John’s Wort in general depressive disorders stronger than for SAD.

In conclusion, while there is some scientific rationale and preliminary evidence for using St. John’s Wort in SAD, the quality and quantity of evidence are modest (rating: 2/5). More rigorous, large-scale studies are needed to confirm its effectiveness specifically for SAD. Anyone considering this supplement should also be aware of its potential interactions with prescription medications and consult a healthcare provider before use.

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