Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tryptophan is an essential amino acid and precursor to serotonin, a neurotransmitter involved in mood regulation. Seasonal Affective Disorder (SAD) is a subtype of depression linked to changes in seasons, typically characterized by lower mood during fall and winter months. The rationale for using tryptophan in SAD is based on its role in serotonin synthesis. Decreased sunlight during winter may lower serotonin activity, potentially contributing to SAD symptoms. Some small clinical studies have explored the efficacy of tryptophan supplementation for depressive symptoms, with mixed results. One controlled trial found that tryptophan was more effective than placebo in alleviating symptoms of SAD, but the sample sizes were small and methodologies varied. Meta-analyses of tryptophan for depression in general suggest a modest benefit, but the quality of evidence is low and few studies focus specifically on SAD. Major treatment guidelines for SAD prioritize light therapy, antidepressants, and psychotherapy, with tryptophan rarely mentioned as a primary or adjunctive intervention. In summary, while there is a plausible biochemical rationale and some preliminary clinical evidence, robust and consistent scientific validation for tryptophan in treating SAD is lacking, resulting in a low overall evidence rating.

More about Tryptophan
More about Seasonal Affective Disorder

Other ingredients used for Seasonal Affective Disorder

Other health conditions supported by Tryptophan

Products containing Tryptophan