Evidence supporting the use of: Aminobutyric acid (unspecified)
For the health condition: Seizures

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Aminobutyric acid most commonly refers to gamma-aminobutyric acid (GABA), which is the primary inhibitory neurotransmitter in the mammalian central nervous system. Its role in the brain involves reducing neuronal excitability, making it crucial in the modulation and prevention of seizures. Scientific validation for the use of GABAergic agents in the treatment of seizures and epilepsy is robust. Many anti-epileptic drugs (AEDs), such as benzodiazepines (e.g., diazepam, lorazepam) and barbiturates (e.g., phenobarbital), function by enhancing the effect of GABA at the GABAA receptor, thereby increasing inhibitory neurotransmission and reducing the likelihood of uncontrolled neuronal firing that leads to seizures.

Direct supplementation with GABA itself is less effective due to poor blood-brain barrier penetration; however, targeting GABAergic pathways pharmacologically is a cornerstone of seizure management. The effectiveness of GABAergic drugs has been demonstrated in numerous clinical trials and is reflected in treatment guidelines for various seizure disorders, including status epilepticus and focal or generalized epilepsies. Thus, the use of aminobutyric acid (specifically in the context of GABA or its analogs) for seizure control is strongly supported by scientific evidence.

More about Aminobutyric acid (unspecified)
More about Seizures

Other health conditions supported by Aminobutyric acid (unspecified)

Anxiety
Epilepsy
Insomnia
Nervousness
Seizures
Sleep (restless and disturbed)
Stress
Tension

Products containing Aminobutyric acid (unspecified)

We currently have no products on Vitabase that contain this ingredient.