Evidence supporting the use of: Beta-hydroxybutyrate
For the health condition: Seizures

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Beta-hydroxybutyrate (BHB) is a ketone body produced during states of low carbohydrate availability, such as fasting or adherence to a ketogenic diet. The ketogenic diet has been used for over a century to treat refractory epilepsy, particularly in children, and its efficacy is well-supported by clinical evidence. The therapeutic effect is attributed largely to the elevated levels of ketone bodies, including BHB, which serve as alternative energy substrates for neurons and may exert anti-seizure effects.

Preclinical studies have demonstrated that BHB can modulate neuronal excitability by influencing neurotransmitter balance, enhancing mitochondrial function, and reducing oxidative stress. More recent research has investigated the direct administration of BHB (e.g., as ketone esters or salts) as a means to induce ketosis without the need for strict dietary adherence. Animal studies and early human trials suggest that exogenous BHB can reduce seizure frequency and severity, though the body of evidence is still growing and most clinical data are derived from ketogenic diet studies rather than isolated BHB supplementation.

Overall, there is robust scientific rationale and growing experimental support for BHB’s use in seizure management, though more high-quality clinical trials are needed to establish the efficacy and safety of exogenous BHB supplementation specifically. The current rating reflects strong foundational science and promising early results, primarily in the context of ketogenic therapy.

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