Evidence supporting the use of: Vitamin B6 (Pyridoxine HCl)
For the health condition: Seizures

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B6 (Pyridoxine HCl) has scientific support for use in a very specific and rare form of seizures known as pyridoxine-dependent epilepsy (PDE). PDE is a genetic metabolic disorder caused by mutations in the ALDH7A1 gene leading to a deficiency in antiquitin, which disrupts normal vitamin B6 metabolism in the brain. This disruption impairs synthesis of neurotransmitters such as gamma-aminobutyric acid (GABA), leading to seizures that are resistant to conventional antiepileptic drugs. Administration of high-dose pyridoxine can stop seizures in affected infants and children, sometimes within minutes to hours, and is life-saving in these cases. This use is well-documented in case reports, clinical series, and reviews (e.g., Baxter P. Pyridoxine-dependent seizures: a clinical and biochemical conundrum. Biochimie. 2013). However, there is no robust evidence to support the use of pyridoxine supplementation for common seizure types or epilepsy in the general population who do not have this rare deficiency. Routine use of Vitamin B6 for seizures outside of PDE is not supported by clinical trials or consensus guidelines. Thus, Vitamin B6 is scientifically validated for a very narrow indication (PDE), but not for seizures in general. The evidence rating reflects this limited but significant application.

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