Evidence supporting the use of: Ketone (unspecified)
For the health condition: Senility

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Ketones, specifically in the form of exogenous ketone supplements or ketogenic diets, have been researched for their potential to support cognitive function in age-related cognitive decline and neurodegenerative conditions, sometimes referred to as "senility." The scientific rationale is based on the brain's ability to utilize ketone bodies (such as beta-hydroxybutyrate) as an alternative energy source when glucose metabolism is impaired, a situation that is seen in aging and in Alzheimer's disease. Several studies have shown that elevating blood ketone levels, either through a ketogenic diet or exogenous ketone supplementation, can improve cognitive performance in elderly individuals with mild cognitive impairment or early Alzheimer's disease. For example, randomized controlled trials have reported modest improvements in memory and executive function following periods of nutritional ketosis.

However, the overall strength of evidence is moderate. Most studies are small, short-term, and sometimes lack rigorous controls. While the metabolic mechanism is plausible and early findings are promising, there is not yet large-scale, long-term clinical evidence confirming that ketones can prevent or significantly reverse "senility." The use of ketone supplementation for cognitive support in the elderly is based on emerging clinical research rather than historical or traditional use. More robust trials are needed to establish efficacy and safety for this indication.

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