Evidence supporting the use of: 5-HTP (test)
For the body system: Serotonin

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

5-HTP (5-hydroxytryptophan) is a naturally occurring amino acid and chemical precursor in the biosynthesis of serotonin, a neurotransmitter that contributes to feelings of well-being and happiness. Scientific validation for the use of 5-HTP to support the serotonin system is based on its role as an intermediate in serotonin production. Supplementation with 5-HTP has been shown in several clinical studies to increase central nervous system serotonin levels, potentially benefiting conditions related to low serotonin, such as depression, anxiety, and insomnia.

Randomized controlled trials have demonstrated that 5-HTP may be more effective than placebo for improving depressive symptoms, though the evidence is less robust compared to standard antidepressant medications. Some studies also indicate potential benefits for anxiety and sleep, although results are mixed and sample sizes are generally small. The safety profile of 5-HTP is generally favorable in the short term, but long-term effects are not well studied, and there are potential risks of serotonin syndrome, especially when combined with other serotonergic medications.

Overall, while 5-HTP use is supported by a reasonable scientific rationale and some clinical evidence, more large-scale, high-quality studies are needed to fully establish its efficacy and safety for supporting the serotonin system.

More about 5-HTP (test)
More about Serotonin

Other body systems supported by 5-HTP (test)

Brain
Glandular System
Pineal Gland
Serotonin
Specific Neurotransmitters

Products containing 5-HTP (test)

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