Evidence supporting the use of: Cacao
For the body system: Serotonin

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cacao (Theobroma cacao) is often associated with mood enhancement and has been suggested to support the serotonin system in the body. Scientifically, cacao contains several compounds relevant to neurotransmitter activity, including tryptophan (a precursor to serotonin), phenylethylamine, and flavonoids. Tryptophan is an amino acid required for serotonin synthesis, and the presence of this compound in cacao provides a plausible mechanism for its effect on the serotonin system. Additionally, cacao’s flavonoids may increase blood flow to the brain and influence neurochemical pathways related to mood.

However, the direct scientific evidence for cacao substantially raising serotonin levels in humans or having a meaningful effect on serotonin-related mood disorders is limited. Most human studies examine chocolate (which contains cacao plus sugar and fats), and findings on mood improvement are often attributed to palatability and energy intake rather than specific neurochemical effects. Animal and in vitro studies do suggest some neurological impacts, but these do not always translate to robust clinical outcomes in humans. Therefore, while there is a scientific rationale and some preclinical data, the clinical evidence supporting cacao as a serotonin system supporter is weak and not definitive.

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