Evidence supporting the use of: Cannabinoids
For the body system: Serotonin

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Cannabinoids, particularly cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), have been studied for their effects on the serotonin system. Research indicates that certain cannabinoids can interact with serotonin (5-HT) receptors, especially the 5-HT1A receptor, which plays a key role in mood regulation, anxiety, and stress response. Preclinical studies in animal models suggest that CBD may exert anxiolytic and antidepressant-like effects at least partially through modulation of the serotonin system. For instance, a 2014 review in the journal Neuropharmacology summarized evidence that CBD enhances serotonergic and glutamate cortical signaling via 5-HT1A receptor activation, which could underlie its observed antidepressant and anxiolytic effects. However, while animal and some early human studies are promising, large-scale, high-quality clinical trials in humans are limited. The evidence is supportive but not conclusive for routine use in serotonin-related conditions such as depression or anxiety. Thus, cannabinoids have a plausible scientific basis for supporting the serotonin system, but the overall quality of evidence is moderate, and more rigorous human studies are needed to establish efficacy and safety.

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