Celastrus, commonly referred to as "Celastrus paniculatus" or "the intellect tree," has a history of use in traditional Ayurvedic medicine for supporting cognitive function and mental health. Traditional texts and anecdotal reports suggest it has been used to improve memory, mental clarity, and to help alleviate symptoms associated with mood disorders, which may be indirectly linked to serotonin modulation. However, these traditional uses are not specifically grounded in a modern understanding of the serotonin system.

Scientific research on Celastrus paniculatus is limited, especially regarding its direct effects on serotonin pathways in the human body. Some animal studies indicate neuroprotective and antidepressant-like effects, potentially implicating monoaminergic systems, but concrete evidence regarding serotonin-specific mechanisms is lacking. No robust clinical trials in humans have directly validated its efficacy for supporting serotonin or treating serotonin-related disorders. Thus, while there is long-standing traditional use for mental well-being, scientific validation for its direct role in serotonin system support remains weak.