Evidence supporting the use of: Fungus
For the body system: Serotonin

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fungi, particularly species such as Hericium erinaceus (Lion's Mane), have been studied for their effects on the serotonin system in the body. Scientific research indicates that certain medicinal mushrooms can influence neurochemical pathways, including those related to serotonin. Lion’s Mane, for example, has demonstrated in animal studies the ability to promote the synthesis of nerve growth factor (NGF) and support neurogenesis, which may indirectly affect mood and cognitive function. Limited preclinical studies suggest it can modulate monoamine neurotransmitters, including serotonin, in the brain. Other fungi, such as Cordyceps and Reishi, have also been shown to have neuroprotective and adaptogenic effects, though direct evidence on serotonin modulation is less robust.

Human clinical trials are still relatively scarce, and most available evidence comes from animal models or in vitro studies. While the historical use of medicinal mushrooms in traditional medicine systems (such as Traditional Chinese Medicine) for mood and cognitive health provides some traditional support, the claim that fungi directly support the serotonin system is primarily based on emerging scientific research rather than established tradition. The current level of evidence, while promising, is not yet strong enough for definitive conclusions, meriting a moderate rating.

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