Evidence supporting the use of: Lupulinum
For the body system: Serotonin

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Lupulinum, a yellowish powder derived from the hop plant (Humulus lupulus), has a long history of use in traditional herbal medicine, predominantly for its sedative and calming effects. Historically, it was recommended for insomnia, restlessness, and anxiety—conditions often associated with low or imbalanced serotonin function—though the mechanisms were not understood. However, explicit references to Lupulinum as a direct support for the "serotonin body system" are lacking in both historical and scientific literature. The rationale for its traditional use is primarily based on the observed effects of hops extracts, which are believed to possess mild sedative properties likely due to constituents such as humulone and lupulone. These compounds may influence neurotransmitter systems, including GABA, but there is minimal direct evidence connecting them to serotonin modulation in humans. Scientific studies on hops and their extracts have focused mainly on their effects in sleep and anxiety, with only limited and indirect suggestions of serotonergic involvement. Therefore, while Lupulinum has been traditionally used for symptoms that overlap with serotonergic dysfunction, the connection is mostly inferential and not strongly evidence-based. Its use for directly supporting the serotonin system should be regarded as traditional, with a modest rating of 2 for evidence strength.

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