Evidence supporting the use of: Mulungu
For the body system: Serotonin

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Mulungu (Erythrina mulungu) is a plant native to South America and has a long history of use in traditional Brazilian and Amazonian herbal medicine. Traditionally, Mulungu bark and extracts are used as natural sedatives, anxiolytics, and sleep aids. The connection to the serotonin system is indirect: traditional uses relate to calming the nervous system, reducing anxiety, and promoting sleep, which are processes often modulated by serotonin. However, clinical research specifically linking Mulungu to serotonin modulation in humans is limited. Some animal studies suggest that Mulungu extracts may have anxiolytic effects, possibly via interaction with neurotransmitter systems, including serotonin, but the precise mechanisms remain unclear. Most available evidence is preclinical, and robust human trials are lacking. As such, while traditional use supports its application for mood and anxiety-related concerns (which may involve serotonin pathways), there is not enough scientific validation specifically for direct serotonin system modulation. Thus, the justification for using Mulungu to support the serotonin body system is primarily traditional, with a low-to-moderate strength of evidence.

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