Evidence supporting the use of: Rhodiola (unspecified)
For the body system: Serotonin

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rhodiola (typically Rhodiola rosea) is a well-known adaptogenic herb used traditionally in Russia, Scandinavia, and parts of Asia to combat fatigue, stress, and support mental performance. Modern scientific research has investigated its effects on mood and neurotransmitter systems, including serotonin. Several animal and in vitro studies have indicated that Rhodiola extracts (especially compounds such as salidroside and rosavin) may influence the central nervous system by modulating levels and activity of neurotransmitters like serotonin, dopamine, and norepinephrine. Some proposed mechanisms include inhibition of monoamine oxidase (MAO), which would reduce the breakdown of serotonin, and enhancement of serotonin transport across the blood-brain barrier.

Human clinical trials on Rhodiola's effects on mood and depressive symptoms provide modest support for its use. A few randomized controlled studies have observed improvements in symptoms of mild to moderate depression and stress-related fatigue, which may be partially mediated by effects on serotonin pathways. However, these studies often involve small sample sizes, varying Rhodiola preparations, and are sometimes limited by methodological weaknesses. There is not yet definitive, large-scale clinical evidence directly linking Rhodiola to robust increases in serotonin or clear therapeutic effects on serotonin-related disorders, but the plausibility and preliminary data justify a mid-level evidence rating.

In summary, both traditional use and emerging scientific evidence suggest Rhodiola may support the serotonin system, though more rigorous studies are needed to confirm the mechanisms and clinical relevance.

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