Evidence supporting the use of: Rosarin
For the body system: Serotonin

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rosarin is a key bioactive compound found in Rhodiola rosea, a plant traditionally used in adaptogenic medicine to reduce stress and improve mood. Scientific interest in rosarin has focused on its potential to modulate neurotransmitter systems, including serotonin. Preclinical studies, particularly those employing Rhodiola rosea extracts (which contain rosarin alongside other compounds like salidroside and rosavin), have demonstrated that these extracts may influence serotonin levels in the brain, likely by inhibiting monoamine oxidase and affecting serotonin reuptake. These mechanisms are hypothesized to contribute to the antidepressant and anxiolytic effects observed in animal models.

However, the majority of clinical studies have used whole plant extracts rather than isolated rosarin. While some human trials suggest Rhodiola supplementation can alleviate symptoms of mild to moderate depression and fatigue, direct evidence regarding rosarin alone is limited. The specific contribution of rosarin, as opposed to other constituents, remains unclear. Thus, while there is a scientific rationale for Rhodiola rosea supporting the serotonin system, the evidence base for rosarin specifically is modest and indirect. More targeted research is needed to clarify rosarin’s individual effects and efficacy on the serotonin system in humans.

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Products containing Rosarin

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