Evidence supporting the use of: Saffranal
For the body system: Serotonin

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Saffranal is a major volatile compound found in saffron (Crocus sativus). There is emerging scientific evidence suggesting that saffranal may influence the serotonin system, which is involved in mood regulation. Preclinical studies (in vitro and in vivo animal models) have found that saffranal exhibits antidepressant-like effects, potentially by inhibiting serotonin reuptake in the brain. These findings are similar to the mechanism of selective serotonin reuptake inhibitors (SSRIs), commonly used antidepressants. Some small human clinical trials, often using whole saffron extracts (which contain saffranal among other compounds), have demonstrated improvements in symptoms of depression and anxiety, though these studies typically do not isolate saffranal as the sole active constituent.

While the exact mechanism is not fully elucidated, saffranal’s modulation of neurotransmitter pathways, including serotonin, is considered a plausible route for its effects. However, most of the direct evidence for saffranal’s action comes from animal studies, and robust, large-scale human trials specifically targeting saffranal are lacking. As a result, the evidence can be considered moderate (rated 3/5): supported by mechanistic studies and some clinical data with saffron extracts, but not yet conclusive for saffranal alone in humans. Nonetheless, saffranal’s inclusion in discussions of serotonin support is grounded in scientific research rather than just traditional use.

More about Saffranal
More about Serotonin

Other body systems supported by Saffranal

Brain
Nerves
Serotonin

Products containing Saffranal

We currently have no products on Vitabase that contain this ingredient.