Evidence supporting the use of: SAM-e
For the body system: Serotonin

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

SAM-e (S-adenosylmethionine) is a compound naturally produced in the body and is involved in methylation reactions, including those that contribute to the synthesis of neurotransmitters such as serotonin. There is scientific evidence supporting the use of SAM-e for mood support, particularly in relation to depression, which is associated with serotonin system dysfunction. Multiple randomized, placebo-controlled trials and meta-analyses have found that SAM-e can be effective in alleviating symptoms of depression, sometimes with efficacy comparable to standard antidepressants. SAM-e is thought to enhance the availability of neurotransmitters such as serotonin, dopamine, and norepinephrine by increasing their synthesis through methylation pathways.

The evidence base includes a 2002 Agency for Healthcare Research and Quality (AHRQ) review and several subsequent systematic reviews, which note that SAM-e appears more effective than placebo and is as effective as tricyclic antidepressants for major depressive disorder. However, while the majority of studies focus on depression rather than direct serotonin measurement, the mechanism is believed to involve serotonin modulation. Safety profiles in studies have generally been favorable, though more research is needed for long-term use and for specific populations.

In summary, SAM-e’s use in supporting the serotonin system is justified by scientific evidence, particularly through its role in mood regulation and depression treatment, though most studies focus on clinical outcomes rather than direct serotonin level measurement.

More about SAM-e
More about Serotonin

Other body systems supported by SAM-e

Brain
Dopamine
Hepatic System
Joints
Liver
Serotonin

Products containing SAM-e

We currently have no products on Vitabase that contain this ingredient.