Evidence supporting the use of: SAMe
For the body system: Serotonin

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

S-Adenosylmethionine (SAMe) is a compound naturally produced in the body that plays a critical role in methylation reactions, which are essential for the synthesis of neurotransmitters, including serotonin. Its use as a supplement to support serotonin-related body systems, such as mood and emotional well-being, is primarily justified by scientific research rather than traditional use.

Clinical studies have shown that SAMe supplementation can have antidepressant effects, which are believed to be mediated, at least in part, by its influence on serotonin metabolism. Randomized controlled trials have demonstrated that SAMe is significantly more effective than placebo in reducing symptoms of major depressive disorder, with some studies suggesting efficacy comparable to standard antidepressants. The proposed mechanism involves increased availability of methyl groups, thereby facilitating the synthesis of serotonin and other monoamine neurotransmitters.

While SAMe is not universally recommended as a first-line therapy due to cost and availability, its safety profile is generally favorable, and it is sometimes used as an adjunct to conventional antidepressants. Major health authorities acknowledge the evidence supporting SAMe’s efficacy in mood disorders, though they also note that more large-scale studies are needed for definitive conclusions.

In summary, SAMe’s use to support the serotonin system is grounded in scientific evidence, particularly regarding its role in mood regulation and depression, with a moderate to strong level of supporting clinical data.

More about SAMe
More about Serotonin

Other body systems supported by SAMe

Brain
Dopamine
Joints
Liver
Serotonin

Products containing SAMe

We currently have no products on Vitabase that contain this ingredient.