Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sceletium, also known as "Kanna," is a succulent plant native to South Africa, traditionally used by indigenous peoples such as the San and Khoikhoi. Its use dates back centuries, primarily as a mood-enhancing substance chewed, smoked, or brewed as tea. The traditional application centers around easing stress, promoting relaxation, and elevating mood, which relates to the body’s serotonin system. The plant contains alkaloids like mesembrine, which have been shown in preliminary in vitro and animal studies to inhibit serotonin reuptake, theoretically increasing serotonin levels in the brain. However, clinical trials in humans are limited, small in size, or of low methodological quality, and the direct effect on the serotonin system in humans remains under-researched. Most contemporary uses of Sceletium for mood or anxiety support reference its longstanding traditional use rather than robust clinical validation. Thus, while there is a plausible mechanism and anecdotal support, the scientific evidence is modest and not yet definitive, warranting a moderate evidence rating based primarily on traditional use.

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