Evidence supporting the use of: Vitamin B6 (not specified)
For the body system: Serotonin

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6, also known as pyridoxine, has scientific support for its role in serotonin synthesis. Vitamin B6 acts as a coenzyme for aromatic L-amino acid decarboxylase, the enzyme responsible for converting 5-hydroxytryptophan (5-HTP) to serotonin. Deficiency in vitamin B6 can impair this conversion, potentially leading to reduced serotonin levels, which are associated with mood disorders such as depression. Several studies have demonstrated that individuals with low vitamin B6 status may have lower serotonin levels and that supplementation can improve certain symptoms related to mood and premenstrual syndrome (PMS), possibly through modulation of serotonin.

However, while the biochemical pathway is well-established, direct clinical evidence supporting the use of vitamin B6 supplementation specifically to boost serotonin levels or treat serotonin-related disorders in the general population is moderate. Most evidence comes from observational studies or research focused on populations with deficiency or specific conditions (e.g., PMS, depression). There are few large-scale, high-quality randomized controlled trials directly linking vitamin B6 supplementation to improved serotonin function or mood in healthy individuals. The evidence is stronger for vitamin B6’s necessity in overall neurotransmitter synthesis but less robust for its efficacy as a stand-alone supplement to enhance serotonin in those with adequate dietary intake.

More about Vitamin B6 (not specified)
More about Serotonin

Other body systems supported by Vitamin B6 (not specified)

Blood
Brain
Glandular System
Immune System
Nerves
Reproductive System
Serotonin

Products containing Vitamin B6 (not specified)

We currently have no products on Vitabase that contain this ingredient.