Evidence supporting the use of: Vitamin B6 (pyridoxamine)
For the body system: Serotonin

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B6, particularly in its active forms pyridoxal 5'-phosphate (PLP), pyridoxine, and pyridoxamine, plays a crucial biochemical role in the synthesis of serotonin, a key neurotransmitter involved in mood regulation. B6 acts as a coenzyme for aromatic L-amino acid decarboxylase, the enzyme responsible for converting 5-hydroxytryptophan (5-HTP) to serotonin. Several studies, both in vitro and in vivo, have shown that B6 deficiency impairs serotonin production and can lead to neurological symptoms such as depression and irritability. Clinical research has demonstrated that supplementation with B6 can improve depressive symptoms in some individuals, especially when combined with other therapies or in populations with marginal B6 status. The connection between B6 and serotonin is well-established at the biochemical level, and the importance of B6 for neurotransmitter synthesis is widely recognized in physiology and psychiatry. However, while the mechanistic evidence is strong, large-scale clinical trials specifically targeting serotonin-related outcomes (like mood disorders) with B6 supplementation alone are limited. Nonetheless, the body of evidence supports the use of B6 in maintaining healthy serotonin levels, especially in individuals at risk for deficiency.

More about Vitamin B6 (pyridoxamine)
More about Serotonin

Other body systems supported by Vitamin B6 (pyridoxamine)

Blood
Brain
Circulatory System
Immune System
Nerves
Serotonin

Products containing Vitamin B6 (pyridoxamine)

We currently have no products on Vitabase that contain this ingredient.