Evidence supporting the use of: Vitamin B6 (Pyridoxine HCl)
For the body system: Serotonin

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine HCl) plays a crucial biochemical role in the synthesis of serotonin, a neurotransmitter involved in mood regulation. Vitamin B6 acts as a coenzyme for aromatic L-amino acid decarboxylase, which converts 5-hydroxytryptophan to serotonin. Deficiency of vitamin B6 has been associated with reduced serotonin production in both animal and human studies. Several clinical studies have explored the impact of vitamin B6 supplementation on mood and depressive symptoms, with mixed but generally positive results, especially in populations with low baseline B6 levels or in combination with other B vitamins.

However, robust, large-scale randomized controlled trials specifically linking vitamin B6 supplementation to increased serotonin levels or improved serotonin-related health outcomes (such as mood or sleep) in healthy adults are limited. Some evidence exists for benefit in special populations, such as individuals with premenstrual syndrome (PMS), where B6 supplementation may help alleviate symptoms, possibly via its effect on neurotransmitter synthesis. Overall, while there is a clear biochemical rationale and some supporting clinical data, the evidence base is not ironclad, and more research is warranted to better define its efficacy in supporting the serotonin system.

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