Evidence supporting the use of: Vitamin B6 (unspecified)
For the body system: Serotonin

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B6 (pyridoxine) plays a key role in the synthesis of several neurotransmitters, including serotonin. It acts as a coenzyme for aromatic L-amino acid decarboxylase, the enzyme responsible for converting 5-hydroxytryptophan (5-HTP) into serotonin. Deficiency in vitamin B6 has been linked with decreased serotonin production, which may negatively impact mood and cognitive function. Some clinical and biochemical studies have shown that low levels of vitamin B6 are associated with depressive symptoms, possibly due to reduced serotonin synthesis (PubMed ID 18689370). Supplementation with B6 has been investigated for its potential to improve mood and reduce symptoms in premenstrual syndrome (PMS), which is thought to involve serotonergic pathways. However, while the biochemical role of B6 in serotonin production is clear, evidence from large, high-quality clinical trials on the efficacy of B6 supplementation specifically to boost serotonin and alleviate mood disorders is limited and mixed. Thus, while the use of vitamin B6 to support the serotonin system is grounded in biochemistry and has some supportive human data, more robust clinical evidence is needed to confirm its effectiveness in this context.

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