Anemarrhena (Anemarrhena asphodeloides), known as Zhimu in traditional Chinese medicine (TCM), has been historically used to "clear heat" and "moisten dryness." In TCM, sinus infections are often associated with patterns of "heat" or "phlegm-heat" in the lung or sinus passages. Zhimu is sometimes included in herbal formulas intended to relieve symptoms such as thick yellow nasal discharge, congestion, or headache related to sinus conditions. The traditional rationale is based on its purported ability to clear heat and reduce inflammation, which are believed to contribute to sinus issues in TCM theory.

However, there is limited direct scientific evidence to support the use of Anemarrhena specifically for sinus infections. Some laboratory and animal studies suggest Anemarrhena contains compounds (such as mangiferin) with anti-inflammatory and antimicrobial effects, but clinical studies in humans addressing sinusitis are lacking. Its inclusion for sinus problems is therefore primarily supported by traditional practice and theoretical mechanisms, rather than robust clinical research.

In summary, while Anemarrhena is traditionally used in TCM formulas for respiratory and sinus conditions, and there is some preclinical rationale, there is little scientific validation specific to sinus infections. The evidence supporting its use for this purpose is primarily traditional and rates low in terms of modern evidence quality.