The use of the Matapalo tree (commonly referring to various Ficus species, such as Ficus aurea or Ficus citrifolia) to support or treat sinus infections is primarily grounded in traditional medicine practices, particularly in regions of Central and South America. In folk medicine, decoctions or infusions of its bark, leaves, or latex have been used for various ailments, including respiratory problems. However, specific documentation of its use for sinus infections is sparse in the scientific literature, and most references to its medicinal use are anecdotal or based on ethnobotanical surveys.

Scientifically, there is limited research investigating the efficacy of Matapalo tree preparations against sinus infections or the typical pathogens involved (such as bacteria or viruses causing sinusitis). Some studies have noted general antimicrobial or anti-inflammatory properties in extracts from Ficus species, but these findings are preliminary and not directly linked to sinusitis treatment. No clinical trials or robust pharmacological studies specifically validate its effectiveness for sinus infections. Therefore, the evidence supporting the use of Matapalo for this purpose remains weak and relies mainly on traditional practice rather than scientific validation.

In summary, the use of the Matapalo tree for sinus infections is based on traditional use, and current scientific evidence supporting this application is minimal to nonexistent.