Premna, a genus of plants in the Lamiaceae family, is commonly used in various traditional medicine systems, particularly in Ayurveda and Southeast Asian folk medicine. In these traditions, certain species such as Premna serratifolia (known as "Agnimantha" in Ayurveda) are used for their purported anti-inflammatory, antimicrobial, and expectorant properties. These properties are believed to help in managing respiratory ailments, including sinus infections (sinusitis).

However, the evidence supporting the use of Premna specifically for sinus infections is largely anecdotal and based on historical usage rather than robust scientific research. Ethnobotanical surveys and traditional medicinal texts cite its use in decoctions or herbal formulations for symptoms like nasal congestion, headache, and respiratory discomfort. Some in vitro studies suggest that extracts of Premna species have antimicrobial and anti-inflammatory activity, but these findings are preliminary and not directly correlated with clinical outcomes in sinus infection patients.

In summary, Premna's application for sinus infections is justified primarily by traditional usage, with minimal direct scientific validation. No well-designed clinical trials have established its efficacy or safety for this specific condition.