Evidence supporting the use of: Flavanones
For the body system: Sinuses

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavanones are a subclass of flavonoids, polyphenolic compounds found abundantly in citrus fruits such as oranges, lemons, and grapefruits. The main flavanones include hesperidin, naringin, and eriocitrin. There is growing scientific interest in their effects on upper respiratory tract health, including the sinuses. Several studies have demonstrated that flavanones possess anti-inflammatory, antioxidant, and mild antimicrobial properties. For example, hesperidin and naringenin have been shown to reduce the production of pro-inflammatory cytokines and inhibit inflammatory pathways in vitro and in animal models, which could help alleviate sinus inflammation. Some small clinical trials and observational studies suggest that citrus bioflavonoids may reduce symptoms of allergic rhinitis and sinusitis, such as nasal congestion, by modulating histamine release and supporting capillary integrity. However, the evidence is still emerging, with most data coming from laboratory and animal research rather than large, well-controlled human trials. Thus, while there is plausible scientific rationale and some preliminary evidence supporting the use of flavanones for sinus health, more robust clinical studies are needed to confirm these effects and determine optimal dosing.

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