Evidence supporting the use of: Flavonones (unspecified)
For the body system: Sinuses

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavanones are a subclass of flavonoids, a group of polyphenolic compounds widely found in citrus fruits such as oranges, lemons, and grapefruits. There is a moderate body of scientific evidence suggesting that flavanones may support the sinuses and respiratory health, primarily due to their anti-inflammatory, antioxidant, and potential anti-allergic properties. Several in vitro and animal studies have shown that flavanones like hesperidin and naringenin can modulate inflammatory pathways, reduce oxidative stress, and inhibit the release of histamines and pro-inflammatory mediators that contribute to sinus inflammation and congestion.

Some small clinical studies and reviews have indicated that citrus bioflavonoids, including flavanones, may help reduce symptoms of allergic rhinitis and sinusitis, although results are not entirely consistent. Their mechanism of action is thought to involve stabilization of mast cells and reduction of mucosal inflammation, which could theoretically ease sinus discomfort. However, large-scale, high-quality clinical trials specifically focusing on "flavanones (unspecified)" in sinus support are lacking, and most available data are based on extracts containing multiple flavonoid types or on animal models.

In summary, while there is some scientific basis for the use of flavanones to support sinus health, the evidence is moderate and not definitive. More rigorous human studies are needed to fully establish their efficacy for this particular body system.

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