Evidence supporting the use of: Goldenseal
For the body system: Sinuses

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Goldenseal (Hydrastis canadensis) has a long history of traditional use in North American herbal medicine, particularly among Native American tribes, who employed it for various mucous membrane conditions, including those affecting the sinuses. The plant contains alkaloids such as berberine, hydrastine, and canadine, which are thought to have antimicrobial and anti-inflammatory properties. In traditional herbal practice, goldenseal has been used as a "mucous membrane tonic" and was popularly included in remedies for sinus congestion, upper respiratory infections, and related symptoms. However, modern clinical research validating goldenseal’s effectiveness specifically for sinus support is limited and largely inconclusive. Some laboratory studies suggest that berberine, a major component, may inhibit certain pathogens and reduce inflammation, but robust human clinical trials are lacking. As a result, while goldenseal’s use for sinus support is deeply rooted in tradition, scientific evidence remains insufficient to confirm its efficacy for this purpose. Caution is also advised, as goldenseal can interact with some medications and is not recommended for prolonged use without professional supervision.

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