The use of "Pungent Principles"—a term generally referring to the bioactive, spicy or aromatic compounds found in plants such as ginger, garlic, horseradish, mustard, and wasabi—to support the sinuses is rooted primarily in traditional and folkloric medicine. Across various cultures, these pungent substances have been employed for centuries to help clear nasal passages and provide relief from sinus congestion. Traditional Chinese Medicine, Ayurveda, and European herbalism have all recognized the effects of pungent herbs and spices in promoting sinus drainage and facilitating breathing, particularly during colds or allergies.

The mechanism is thought to involve the irritation or stimulation of mucous membranes, promoting increased mucus secretion and helping to clear blockages. For example, horseradish and mustard are used in herbal traditions as sinus-clearing remedies because of their volatile oils, which can trigger a reflexive increase in nasal secretions. Garlic and ginger are also frequently mentioned in historical texts for their expectorant and anti-inflammatory properties, although these effects are primarily supported by anecdotal and traditional use rather than rigorous clinical studies.

While there is some preliminary scientific investigation into the antimicrobial or anti-inflammatory effects of individual pungent compounds, robust clinical evidence specifically validating their efficacy for sinus health is limited. Thus, the primary justification for their use in supporting sinus health remains traditional.