Evidence supporting the use of: Serralysin
For the body system: Sinuses

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Serralysin (also known as serrapeptase) is a proteolytic enzyme originally isolated from the bacterium Serratia marcescens. It is often marketed as a supplement for supporting sinus health, primarily due to its purported ability to reduce inflammation and break down mucus or "biofilms" in the respiratory tract. Some clinical studies and laboratory research suggest that serralysin may have anti-inflammatory effects that could theoretically benefit sinus health by reducing swelling and promoting drainage. For example, small human studies and animal models have found serrapeptase may reduce inflammatory markers and help liquefy viscous secretions, which could help clear blocked sinuses.

However, the scientific evidence supporting its efficacy for sinus support remains limited and of low quality. Most studies are small, lack rigorous controls, or focus on broader anti-inflammatory or mucolytic effects rather than direct sinus outcomes. The mechanism of action—proteolytic cleavage of inflammatory mediators and mucus proteins—remains plausible, but definitive, high-quality clinical trials in patients with sinusitis or chronic sinus congestion are lacking.

In summary, while serralysin is justifiably used for sinus support based on some scientific rationale and preliminary evidence, the strength of the evidence is weak (rated 2/5). More robust clinical research is needed to confirm its benefits for the sinus body system.

More about Serralysin
More about Sinuses

Other body systems supported by Serralysin

Arteries
Blood
Circulatory System
Immune System
Joints
Sinuses

Products containing Serralysin

We currently have no products on Vitabase that contain this ingredient.