Evidence supporting the use of: Alpha-ketoglutarate (AKG)
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-ketoglutarate (AKG) has been investigated for its potential role in supporting bone health, with some scientific studies providing preliminary evidence for its benefit to the skeletal system. AKG is a key intermediate in the Krebs cycle and plays a role in amino acid metabolism and energy production. Animal studies, particularly in rodents and chickens, have indicated that dietary AKG supplementation may promote bone mineralization and increase bone density. For example, research has shown that AKG can enhance calcium absorption and positively affect markers of bone formation. In vitro studies have suggested that AKG may influence osteoblast (bone-forming cell) differentiation and activity, potentially by modulating signaling pathways related to bone growth.

However, direct evidence from human clinical trials is currently limited. Most human research on AKG has focused on its use in clinical nutrition (such as reducing muscle wasting or supporting wound healing) rather than specifically targeting bone health. Some small studies in elderly or osteoporotic populations have hinted at possible benefits, but robust, large-scale clinical data are lacking. Overall, the current scientific evidence supporting AKG for skeletal system support is modest and primarily based on preclinical models rather than strong clinical trial data. Therefore, while there is a plausible scientific rationale and some supporting evidence, more research—particularly in humans—is needed to confirm its efficacy for bone health.

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