Evidence supporting the use of: Chrondroitin sulfate
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Chondroitin sulfate is a compound naturally found in cartilage around joints in the body and is commonly used as a dietary supplement to support joint health. Its use is primarily linked to the management of osteoarthritis, rather than direct support for bone health. Scientific studies have investigated the effectiveness of chondroitin sulfate, chiefly for its purported benefits in reducing joint pain and improving joint function. A number of randomized controlled trials and meta-analyses suggest that chondroitin sulfate, often in combination with glucosamine, may provide modest symptomatic relief in osteoarthritis, particularly of the knee. However, the clinical significance of these effects is debated, with some studies reporting little to no benefit compared to placebo.

There is limited evidence that chondroitin sulfate directly improves bone density or bone strength. Its primary mechanism is thought to be the inhibition of cartilage breakdown and possibly anti-inflammatory effects within the joint space. Major guidelines, such as those from the American College of Rheumatology, do not universally recommend chondroitin for osteoarthritis due to inconsistent findings. In summary, scientific evidence supports a minor role for chondroitin sulfate in joint (cartilage) health, but not in direct support of bone health, so its use for the skeletal system as a whole is supported by low to moderate quality evidence.

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Other body systems supported by Chrondroitin sulfate

Joints
Skeletal System (Bones)

Products containing Chrondroitin sulfate

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