Evidence supporting the use of: Devil's claw
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Devil's claw (Harpagophytum procumbens) is most commonly used in herbal medicine for its anti-inflammatory and analgesic effects, particularly in the context of musculoskeletal health. Scientific research has focused on its potential benefits in managing symptoms of osteoarthritis, back pain, and other joint disorders. Several randomized controlled trials and systematic reviews suggest that devil's claw extract can reduce pain and improve mobility in people with osteoarthritis and low back pain, often comparably to standard pain medications such as NSAIDs, but with fewer side effects.

The main active compounds, harpagosides, are believed to exert anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators. Although devil's claw does not directly support bone density or structure, its efficacy in reducing joint pain and inflammation indirectly supports the skeletal system by improving function and quality of life in individuals with degenerative joint conditions. The evidence base is moderate, with most studies focused on symptom relief rather than disease modification or bone health per se. Overall, devil's claw is scientifically validated for supporting the skeletal system primarily through its effects on pain and inflammation in joints.

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Other body systems supported by devil's claw

Joints
Muscles
Skeletal System (Bones)
Structural System