Evidence supporting the use of: Fibroblast growth factor
For the body system: Skeletal System (Bones)

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fibroblast Growth Factor (FGF) is a family of proteins involved in a variety of biological processes, including cell growth, development, tissue repair, and angiogenesis. Scientific evidence supports the role of certain FGFs, particularly FGF2 (basic FGF), in skeletal development and bone repair. FGFs are critical regulators of chondrogenesis (the formation of cartilage) and osteogenesis (the formation of bone). Mutations in FGF receptors are known to cause skeletal disorders such as achondroplasia, underscoring their physiological significance in bone development. Preclinical studies have shown that exogenous FGF2 can stimulate the proliferation and differentiation of osteoblasts (bone-forming cells) and enhance fracture healing in animal models.

However, the clinical use of FGFs for bone health in humans is still largely experimental. While FGFs have been investigated as therapeutic agents for bone regeneration in tissue engineering and orthopedic research, there are currently no approved FGF-based therapies for the general support of the skeletal system in humans. Most evidence comes from laboratory and animal studies, with limited human trials. Thus, while the scientific rationale is strong, and there is preclinical validation, direct clinical evidence is limited, warranting a moderate rating for the strength of evidence.

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