Evidence supporting the use of: Flavonoid (mixture)
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonoids are a diverse group of plant-derived polyphenolic compounds found in fruits, vegetables, and other plant-based foods. There is a growing body of scientific research exploring their effects on bone health and the skeletal system. Preclinical studies, mainly in animal models and cell cultures, suggest that flavonoids may promote osteoblast activity (bone-forming cells), inhibit osteoclast differentiation (bone-resorbing cells), and modulate signaling pathways involved in bone metabolism, such as the RANKL/OPG system. Certain subclasses of flavonoids, such as isoflavones (e.g., genistein from soy) and flavonols (e.g., quercetin), have been studied more extensively and show potential in supporting bone mineral density and reducing bone loss. Human observational studies have associated higher dietary flavonoid intake with increased bone mineral density and reduced risk of osteoporosis, particularly in postmenopausal women. However, randomized controlled trials are limited in number and often use specific isolated flavonoids at varying doses, rather than mixture formulations. While results are promising, more well-designed clinical trials are needed to confirm the efficacy and optimal dosing of flavonoid mixtures for skeletal support. In summary, there is moderate scientific evidence from laboratory and some human studies supporting the use of flavonoids for bone health, but the evidence for flavonoid mixtures (as opposed to single compounds) and their direct clinical application remains incomplete.

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