Evidence supporting the use of: Isoflavone (unspecified)
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isoflavones, primarily found in soy products, have been studied for their potential benefits in supporting bone health, particularly in postmenopausal women. Isoflavones are phytoestrogens, plant-derived compounds with estrogen-like activity, and estrogen is known to play a critical role in maintaining bone density. Several clinical trials and meta-analyses suggest that isoflavone supplementation may moderately improve bone mineral density (BMD) and reduce bone resorption in postmenopausal women, likely due to their weak estrogenic effects. For example, a 2017 meta-analysis published in Osteoporosis International reported that isoflavone supplementation led to a modest but statistically significant improvement in lumbar spine BMD. However, results are somewhat mixed, with some studies showing minimal or no effect, and the benefits appear to be more pronounced in populations with low endogenous estrogen, such as postmenopausal women. There is less evidence supporting isoflavone use for bone health in men or premenopausal women. While isoflavones are not universally endorsed as a primary treatment for osteoporosis, current scientific literature does provide some validation for their supportive role in bone health, especially as an adjunct to standard therapies.

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Products containing isoflavone (unspecified)

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