Evidence supporting the use of: Polyphenols (mixed)
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polyphenols are a diverse group of naturally occurring compounds found in plants, known for their antioxidant and anti-inflammatory properties. There is emerging, but limited, scientific evidence suggesting polyphenols may support skeletal health. Several in vitro and animal studies have shown that certain polyphenols (such as those found in green tea, grapes, and berries) may promote osteoblast activity (bone formation) and inhibit osteoclast activity (bone resorption), potentially benefiting bone density. Some human observational studies have found associations between higher polyphenol intake and markers of better bone health, but causality has not been firmly established.

For example, flavonoids, a major polyphenol subgroup, have been linked in some cohort studies to higher bone mineral density in postmenopausal women. However, randomized controlled trials in humans are scarce, and results are mixed. The mechanisms are thought to involve polyphenols' ability to reduce oxidative stress and inflammation, both of which negatively impact bone remodeling. Despite this, there is not enough robust clinical evidence to firmly recommend mixed polyphenols specifically for bone health.

In summary, while there is a scientific rationale and some preliminary evidence for polyphenols supporting skeletal health, high-quality human trials are lacking, and the evidence is currently limited. Thus, the use of mixed polyphenols for bone support is rated as 2 out of 5 for scientific evidence.

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