Evidence supporting the use of: Proteoglycans
For the body system: Skeletal System (Bones)

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proteoglycans are large molecules consisting of a protein core with glycosaminoglycan (GAG) side chains, and they are critical components of the extracellular matrix in connective tissues, including cartilage and bone. Scientific research supports their role in maintaining the structural integrity and function of cartilage, which indirectly supports bone health by preserving joint function and cushioning. Specifically, proteoglycans help absorb mechanical shock and provide resistance to compression in articular cartilage, which covers bone ends within joints. Alterations or loss of proteoglycans are associated with degenerative joint diseases, such as osteoarthritis.

Supplementation or therapeutic use of specific proteoglycan extracts (often derived from animal cartilage) has been investigated for joint health, with some clinical studies suggesting potential benefits for symptoms of osteoarthritis, such as reduced pain and improved joint function. However, direct scientific evidence that oral or supplemental proteoglycans significantly enhance bone density or directly impact bone tissue is limited. Most of the research relates to joint cartilage rather than bone itself. Therefore, while there is a mechanistic basis and some clinical research supporting their use for joint (and by extension, skeletal system) health, the evidence is moderate and not as strong as for other interventions like calcium or vitamin D for bones.

More about Proteoglycans
More about Skeletal System (Bones)

Other body systems supported by Proteoglycans

Intestinal System
Joints
Skeletal System (Bones)
Skin

Products containing Proteoglycans

We currently have no products on Vitabase that contain this ingredient.