Solomon's seal (Polygonatum spp.) has a long history of use in traditional medicine systems, particularly in Traditional Chinese Medicine (TCM) and various European folk traditions. In these systems, the root of Solomon's seal has been used to support joint health, aid in the healing of broken bones, and address connective tissue issues such as sprains, strains, and bruises. The rationale was largely based on the doctrine of signatures and empirical observations, where the knobby appearance of the root was thought to resemble joints and bones, thus indicating its use for musculoskeletal complaints.

Scientifically, there is a lack of robust clinical evidence to validate the effectiveness of Solomon's seal specifically for supporting bone health or the skeletal system. Most studies focus on its anti-inflammatory, antioxidant, and immune-modulating properties, with limited research on its direct effects on bone metabolism or healing. In vitro and animal studies have suggested potential benefits for connective tissues, but these findings have not been translated into well-controlled human clinical trials.

In summary, the use of Solomon's seal for skeletal system support is primarily justified by traditional use, not by modern scientific validation. Its popularity in herbal medicine for bone and joint issues persists, but the evidence base remains limited and largely anecdotal.