Evidence supporting the use of: Soy
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Soy is scientifically studied for its potential benefits to the skeletal system, especially in relation to bone health in postmenopausal women. Soybeans are rich in isoflavones, particularly genistein and daidzein, which are classified as phytoestrogens—plant-derived compounds that can mimic the effects of estrogen in the body. Since estrogen plays a crucial role in maintaining bone density, the decline in estrogen during menopause is associated with increased risk of osteoporosis and bone loss. Several randomized controlled trials and meta-analyses have investigated the effects of soy isoflavones on bone mineral density (BMD). Some studies have found that soy isoflavone supplementation can modestly increase or help maintain BMD in postmenopausal women, especially at the lumbar spine, although the effects are generally less pronounced than those achieved with conventional hormone replacement therapy. A 2019 meta-analysis in Osteoporosis International concluded that soy isoflavones have a small but significant positive effect on spinal BMD. However, there is variability in individual response, and not all studies show benefit. In summary, there is a moderate level of scientific evidence supporting soy’s role in supporting bone health, particularly in populations at risk of estrogen deficiency, though it should not be considered a replacement for established osteoporosis treatments.

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