Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin D3 (cholecalciferol) is scientifically validated in its role supporting the skeletal system, particularly bone health. Vitamin D3 is essential for calcium absorption in the intestines, which is critical for maintaining proper bone mineralization and strength. Deficiency in vitamin D3 leads to impaired bone mineralization, resulting in conditions such as rickets in children and osteomalacia or osteoporosis in adults. Multiple randomized controlled trials and meta-analyses have demonstrated that adequate vitamin D3 intake, often in combination with calcium, reduces bone loss and fracture risk, especially in older adults.

Regulatory bodies such as the Institute of Medicine (now the National Academy of Medicine) and the Endocrine Society recognize vitamin D’s central role in bone health, recommending supplementation in cases of deficiency or limited sun exposure. The robust scientific consensus is reflected in clinical guidelines worldwide. Furthermore, vitamin D receptors are present in bone cells (osteoblasts and osteoclasts), and vitamin D3 directly influences bone remodeling processes.

In summary, the use of vitamin D3 to support the skeletal system is supported by high-quality scientific evidence and is a standard medical practice for preventing and treating bone disorders related to vitamin D deficiency.

More about vitamin D3
More about Skeletal System (Bones)

Other ingredients that support Skeletal System (Bones)

Other body systems supported by vitamin D3

Products containing vitamin D3

Designs For Health Acnutrol™
Designs For Health ADK-Evail™
Metagenics AdvaClear
Metagenics AdvaClear
Thorne Advanced Bone Support Oscap
Thorne Advanced Nutrients Multivitamin
Metagenics Akkermansia Co.™ Healthy Weight with Glucose Control
Metagenics Axis Endo™ Mango
Pure Encapsulations Balanced Immune
Thorne Basic Nutrients 2/Day Multivitamin
Thorne Basic Prenatal Multivitamin
Designs For Health BioFizz® Immune
Metagenics Bone Builder Active
Metagenics Bone Builder Chewable Chocolate
Metagenics Bone Builder Plus
Metagenics Bone Builder Forte
Metagenics Bone Builder Magnesium
Metagenics Bone Builder Prime
Metagenics Bone Builder with Magnesium
Douglas Laboratories C-D-Zinc
Pure Encapsulations Cal/Mag/D
Pure Encapsulations CAL+ with Ipriflavone
Pure Encapsulations CAL+ with Ipriflavone
Pure Encapsulations Calcium K/D
Designs For Health Calcium Malate
Pure Encapsulations Calcium with Vitamin D3
Designs For Health Chromium Synergy™
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 10-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 10-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus pH Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Pineapple Banana
Metagenics Clear Change 28-Day Detox Program with UltraClear Plus Vanilla
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Berry
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Chai
Metagenics Clear Change 28-Day Detox Program with UltraClear RENEW Vanilla
Metagenics Clear Change Daily Essentials
Integrative Therapeutics Clinical Nutrients HP
Pure Encapsulations Cortisol Calm
Pure Encapsulations Cortisol Calm
Designs For Health D Evail™ 10K
Designs For Health D-Evail™ Supreme
Pure Encapsulations Daily Immune
Designs For Health DFH Complete Multi™
Designs For Health DFH Complete Multi™ with Copper
Designs For Health Emulsi-D3 Synergy™
Pure Encapsulations EmulsiSorb K2D3
Pure Encapsulations Energize Plus™ Pure Pack
Metagenics Fem Prenatal®
Metagenics GI Sustain™ Powder
Designs For Health Hi-Po Emulsi-D3™
Metagenics ImmuCore
Metagenics Immune Defense Pack
Integrative Therapeutics ITI Vitamin D3 5000 iu
Integrative Therapeutics K-PAX MitoNutrients
Douglas Laboratories K2-D3 with Astaxanthin
Metagenics Ketogenic Shake Chocolate
Metagenics Ketogenic Shake Vanilla
Klean Athlete Klean-D 1000
Klean Athlete Klean-D ™ 5000 IU
Klean Athlete Klean Essential Aminos + HMB®
Klean Athlete Klean Multivitamin ™
Designs For Health Liposomal Cat's Claw
Designs For Health Liposomal D Supreme
Douglas Laboratories Liquid Cal/Mag/D
Integrative Therapeutics Liquid Calcium Magnesium Berry Flavored
Integrative Therapeutics Liquid Calcium Magnesium Orange Vanilla
Douglas Laboratories Liquid D and K (DISCONTINUED)
Douglas Laboratories Liquid Multivitamin
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Integrative Therapeutics Magtein L-Threonate Plus
Thorne MediClear Plus
Thorne Men's Multi 50+
Designs For Health Metabolic Synergy™
Designs For Health Metabolic Synergy™
Metagenics MetaGlycemX™
Metagenics MetaGlycemX
Metagenics MetaKids Multi Soft Chew Grape
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Metagenics MetaKids Vitamin D3 Liquid
Douglas Laboratories Methlyated Resveratrol Plus
Pure Encapsulations Multi t/d
Pure Encapsulations Multi t/d
Metagenics Multigenics®
Metagenics Multigenics Chewable Orange
Metagenics Multigenics Intensive Care
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Metagenics Multigenics without Iron
Douglas Laboratories Muscle Protect™ with HMB®
Designs For Health MyoStim™
Pure Encapsulations NeuroMood Pure Pack
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950®
Pure Encapsulations Nutrient 950® A without Copper & Iron
Pure Encapsulations Nutrient 950® with NAC
Pure Encapsulations Nutrient 950® with Vitamin K
Pure Encapsulations Nutrient 950® without Copper, Iron & Iodine
Pure Encapsulations Nutrient 950® without Iron
Pure Encapsulations Nutrient 950® without Iron
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Designs For Health OmegAvail™ Ultra with Vitamin D3, K1 and K2
Pure Encapsulations OsteoBalance
Pure Encapsulations OsteoBalance
Designs For Health Osteoben®
Designs For Health OsteoForce™
Designs For Health OsteoForce™
Designs For Health OsteoForce™ Supreme
Integrative Therapeutics Osteoprime Forte
Integrative Therapeutics Osteoprime Ultra
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™ Detox Program
Designs For Health PaleoCleanse Plus™Chocolate Detox Kit
Integrative Therapeutics Physicians Elemental Diet Dextrose Free
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physician's Elemental Diet
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Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
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Designs For Health Plant Protein Cleanse
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Metagenics PlusOne® Daily Prenatal Packs
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Pure Encapsulations Polyphenol Nutrients
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Pure Encapsulations PreNatal Nutrients
Pure Encapsulations PreNatal Nutrients
Designs For Health Prenatal Pro™
Designs For Health Primal Multi™
Designs For Health Prostate Supreme™
Designs For Health Prostate Supreme™
Integrative Therapeutics ProThrivers Multivitamin
Pure Encapsulations PureDefense with NAC
Pure Encapsulations PureDefense with NAC
Pure Encapsulations PureGenomics® UltraMultivitamin
Pure Encapsulations PureHeart® K2D
Pure Encapsulations PureLean® Protein
Pure Encapsulations PurePals with Iron
Pure Encapsulations PureResponse™ Multivitamin
Douglas Laboratories QUELL Fish Oil ® - EPA/DHA Plus D
Pure Encapsulations Sereniten Plus
Douglas Laboratories Sereniten Plus
Pure Encapsulations SP Ultimate
Pure Encapsulations SP Ultimate
Pure Encapsulations Synergy K
Pure Encapsulations Synergy K
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Pure Encapsulations Thyroid Support Complex
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Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Metagenics Ultra Glucose Control® Chocolate
Metagenics Ultra Glucose Control Chocolate
Metagenics Ultra Glucose Control Vanilla
Metagenics Ultra Glucose Control Vanilla
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ® 2 Daily
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories Ultra Preventive ® Kids Grape Flavor
Douglas Laboratories Ultra Preventive ® Kids Orange Flavor
Douglas Laboratories Ultra Preventive One Daily
Douglas Laboratories Ultra Preventive® X
Metagenics Ultra Prostagen Concentrated
Douglas Laboratories Ultra Protein Green
Pure Encapsulations Ultra Pure Pack
Metagenics UltraClear Detox Powder
Metagenics UltraClear Plus® Detox Powder
Metagenics UltraClear Plus Detox Powder Berry
Metagenics UltraClear Plus Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Pineapple/Banana
Metagenics UltraClear Plus pH Detox Powder Vanilla
Metagenics UltraClear RENEW Detox Powder Berry
Metagenics UltraClear RENEW Detox Powder Chai
Metagenics UltraClear RENEW Detox Powder Vanilla
Pure Encapsulations UltraDetox 10-Day Pure Pack
Metagenics UltraGI Replenish® Chocolate
Metagenics UltraGI Replenish Chocolate
Metagenics UltraGI Replenish Vanilla
Metagenics UltraGI Replenish Vanilla
Metagenics UltraInflamX Plus 360°® Chocolate/Orange
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Mango
Metagenics UltraInflamX Plus 360° Orange
Metagenics UltraInflamX Plus 360° Original Spice
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraInflamX Plus 360° Pineapple/Banana
Metagenics UltraMeal Advanced Protein® Dutch Chocolate
Metagenics UltraMeal Advanced Protein French Vanilla
Metagenics UltraMeal Advanced Protein Plain
Metagenics UltraMeal Cardio 360°® Pea/Rice Chocolate
Metagenics UltraMeal Cardio 360° Pea/Rice Vanilla
Metagenics UltraMeal® Daily Support Dutch Chocolate
Metagenics UltraMeal Daily Support Mixed Berry
Metagenics UltraMeal Rice Vanilla
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations VisionPro Nutrients
Thorne Vitamin D-1,000
Douglas Laboratories Vitamin D 1,000 I.U.
Thorne Vitamin D-10,000
Vitabase Vitamin D-3
Douglas Laboratories Vitamin D 5,000 I.U.
Douglas Laboratories Vitamin D 5,000 I.U.
Thorne Vitamin D-5000 NSF
Thorne Vitamin D + K2
Thorne Vitamin D Liquid
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Synergy
Pure Encapsulations Vitamin D3
Pure Encapsulations Vitamin D3 10 mcg 400 IU
Metagenics Vitamin D3 1000™
Vitabase Vitamin D3 1000 IU
Metagenics Vitamin D3 10,000 + K
Pure Encapsulations Vitamin D3 125 mcg 5,000 IU
Pure Encapsulations Vitamin D3 125 mcg 5,000 IU
Pure Encapsulations Vitamin D3 125 mcg 5,000 IU
Metagenics Vitamin D3 2000 Complex
Integrative Therapeutics Vitamin D3 2000 iu
Pure Encapsulations Vitamin D3 25 mcg 1,000 IU
Pure Encapsulations Vitamin D3 25 mcg 1,000 IU
Pure Encapsulations Vitamin D3 25 mcg 1,000 IU
Pure Encapsulations Vitamin D3 250 mcg 10,000 IU
Pure Encapsulations Vitamin D3 250 mcg 10,000 IU
Metagenics Vitamin D3 5000
Metagenics Vitamin D3 5000 + K
Metagenics Vitamin D3 Liquid
Pure Encapsulations Vitamin D3 Vegan
Pure Encapsulations Vitamin D3 Vegan
Pure Encapsulations Vitamin D3 VESIsorb®
Integrative Therapeutics Vitamin K2+D3
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Designs For Health Women's Twice Daily Essential Packets