Evidence supporting the use of: Vitamin K (Phylloquinone)
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin K, particularly in the form of phylloquinone (vitamin K1), plays a scientifically validated role in supporting the skeletal system. Vitamin K is essential for the post-translational modification of osteocalcin, a protein synthesized by osteoblasts (bone-forming cells). This modification allows osteocalcin to bind calcium ions, facilitating their incorporation into the bone matrix and thus contributing to bone mineralization and strength. Multiple observational and interventional studies have shown that low levels of vitamin K are associated with an increased risk of bone fractures and lower bone mineral density, especially in postmenopausal women and older adults. Randomized controlled trials have demonstrated that vitamin K supplementation can improve biochemical markers of bone health, though the impact on fracture rates is less clear and may depend on population and dosage. The Institute of Medicine and other expert groups recognize vitamin K’s essential role in bone metabolism, although they note that for most healthy individuals, dietary sufficiency is generally achieved through green leafy vegetables and that supplementation is mainly considered in deficiency states. Overall, the evidence supports a significant, scientifically validated role for vitamin K in maintaining bone health, though it is not typically used as a standalone treatment for osteoporosis.

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Other body systems supported by Vitamin K (Phylloquinone)

Arteries
Blood
Capillaries
Circulatory System
Heart
Hepatic System
Skeletal System (Bones)

Products containing Vitamin K (Phylloquinone)

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