Methylsulfonylmethane (MSM) is a sulfur-containing compound commonly used as a dietary supplement for various health purposes, including skin health. Scientific evidence supporting MSM’s role in skin health is limited but emerging. Several small-scale clinical studies and laboratory experiments suggest that MSM may help improve skin condition by reducing inflammation, supporting collagen production, and providing antioxidant benefits. For example, a randomized, double-blind, placebo-controlled study published in 2015 found that oral MSM supplementation improved skin firmness, elasticity, and hydration in participants after 16 weeks. Other studies have explored MSM’s potential to reduce symptoms of rosacea and alleviate skin irritation, though these are generally preliminary and involve small sample sizes.

Proposed mechanisms for MSM’s effects on the skin include its ability to donate sulfur for the synthesis of keratin and collagen, two essential proteins for skin structure and strength. MSM may also exert anti-inflammatory and antioxidant effects, which could help protect the skin from damage and support its repair processes. Despite this, the overall quality and quantity of clinical evidence remain modest, and most findings are based on short-term studies with limited participant numbers. Larger, well-controlled clinical trials are needed to confirm these benefits and establish optimal dosages.

In summary, while scientific evidence for MSM’s benefits for skin health is limited, early findings are promising, justifying a moderate rating.