Evidence supporting the use of: Azelaic acid
For the health condition: Skin Care (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Azelaic acid is widely used in general skin care due to its multifaceted dermatological benefits, and its efficacy is supported by a substantial body of scientific evidence. Azelaic acid is a naturally occurring dicarboxylic acid found in grains such as wheat, rye, and barley. In dermatology, it is primarily recognized for its antimicrobial, anti-inflammatory, and keratolytic properties. These effects make it beneficial for common skin issues such as acne, rosacea, hyperpigmentation, and uneven skin texture.

Clinical studies have demonstrated that azelaic acid inhibits the growth of Propionibacterium acnes (the bacteria involved in acne) and reduces the production of keratin, a protein that can block pores and lead to acne formation. Additionally, it has been shown to reduce inflammation, which is a key factor in both acne and rosacea. Azelaic acid also inhibits tyrosinase, an enzyme involved in melanin production, making it effective in addressing hyperpigmentation and melasma.

Over-the-counter formulations (typically 10%) and prescription strengths (15-20%) are both used, with the latter being approved by regulatory agencies such as the FDA for the treatment of acne and rosacea. Side effects are generally mild and may include temporary burning or tingling upon application. Overall, scientific research, including randomized controlled trials and meta-analyses, supports the use of azelaic acid as a safe and effective option for improving skin texture, reducing inflammation, and treating pigmentary disorders.

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Products containing azelaic acid

We currently have no products on Vitabase that contain this ingredient.