Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Hyaluronic acid (HA) is widely recognized in dermatology and skincare due to its strong scientific foundation for supporting skin hydration and overall skin health. HA is a naturally occurring glycosaminoglycan found in the skin’s extracellular matrix, where it plays a critical role in maintaining moisture, elasticity, and tissue repair. Its remarkable ability to bind and retain water—holding up to 1,000 times its weight—makes it an effective humectant when applied topically.

Multiple clinical studies support topical HA’s efficacy in improving skin hydration, smoothness, and elasticity. Randomized controlled trials have demonstrated that HA-containing creams and serums significantly increase skin moisture and reduce the appearance of fine lines. HA’s large molecular size generally limits deep skin penetration, but smaller molecular weight forms can penetrate deeper layers, further enhancing hydration. Additionally, HA is non-irritating and suitable for sensitive skin, making it a favored ingredient in both over-the-counter and professional formulations.

Beyond hydration, HA may also support wound healing and barrier function, as evidenced by in vitro and animal studies, though these effects are less established in cosmetic use. Overall, the regular use of HA is scientifically validated for general skin care, primarily for improving skin moisture and appearance, with a strong body of clinical and mechanistic evidence supporting its benefits.

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Other health conditions supported by hyaluronic acid

Products containing hyaluronic acid

Designs For Health ArthroSoothe™
Pure Encapsulations Hyaluronic Acid
Pure Encapsulations Hyaluronic Acid
Douglas Laboratories Hyaluronic Acid®
Douglas Laboratories Hydrolyzed Collagen+
Pure Encapsulations Joint Complex
Pure Encapsulations Joint Complex