Evidence supporting the use of: Lithospermum erythrorhizon
For the health condition: Skin Care (general)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Lithospermum erythrorhizon, also known as "Zi Cao" in traditional Chinese medicine (TCM), has a long history of use for various skin conditions. Traditionally, its dried root is employed in formulations to treat skin ailments such as eczema, burns, sores, and inflammation. The root contains naphthoquinone pigments (notably shikonin and its derivatives), which were believed to provide anti-inflammatory, antimicrobial, and wound-healing properties. In TCM, Lithospermum erythrorhizon is commonly included in topical ointments (such as the famous "Purple Cloud Ointment," or "Zi Yun Gao") for treating burns and promoting skin regeneration.

Modern scientific studies, mostly in vitro and animal research, have supported some of these traditional uses. Shikonin and related compounds have demonstrated anti-inflammatory, antimicrobial, and wound-healing effects in laboratory settings. For example, shikonin has been shown to inhibit certain inflammatory pathways and promote tissue repair in animal models. However, robust clinical trials in humans are still limited. Thus, while there is a strong traditional basis and some promising preliminary scientific evidence, the overall body of evidence supporting its use for general skin care remains moderate and is not yet fully substantiated by high-quality clinical research.

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