Lubricants, particularly in the form of moisturizers and emollients, are scientifically validated for their use in general skin care. These products are formulated to reduce transepidermal water loss, maintain skin barrier function, and provide relief from dryness and irritation. Numerous clinical studies have demonstrated that lubricants containing ingredients such as petrolatum, mineral oil, lanolin, and dimethicone are effective in improving skin hydration and elasticity, especially in conditions like xerosis (dry skin), eczema, and psoriasis. By forming a protective layer on the skin's surface, these agents help prevent moisture loss and protect against external irritants.

The American Academy of Dermatology and other dermatological organizations recommend regular use of lubricants for maintaining healthy skin and managing a range of dermatological conditions. Evidence supports both the prevention and treatment of dry, flaky, or irritated skin through the consistent application of lubricants. These benefits are supported by randomized controlled trials and systematic reviews, which confirm improvements in skin barrier function and symptomatic relief in both healthy and diseased skin. While the precise formulation and choice of lubricant may vary based on individual needs and sensitivities, their general efficacy in skin care is well-established in the scientific literature.